4ITH
Crystal structure of RIP1 kinase in complex with necrostatin-1 analog
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Receptor-interacting serine/threonine-protein kinase 1 | polymer | 294 | 33468.7 | 2 | UniProt (Q13546) Pfam (PF07714) | Homo sapiens (human) | Cell death protein RIP, Receptor-interacting protein 1, RIP-1, Serine/threonine-protein kinase RIP |
| 2 | C, D, E, F, G... (A, B) | IODIDE ION | non-polymer | 126.9 | 10 | Chemie (IOD) | |||
| 3 | H, O (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | I, P (A, B) | (5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione | non-polymer | 277.7 | 2 | Chemie (RCM) | |||
| 5 | Q, R (A, B) | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 294 (UniProt: Q13546)
| PDB | External Database | Details |
|---|---|---|
| Ala 34 | Cys 34 | engineered mutation |
| Ala 127 | Cys 127 | engineered mutation |
| Ala 233 | Cys 233 | engineered mutation |
| Ala 240 | Cys 240 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66937.5 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1870.4 | |
| All* | Total formula weight | 68807.9 |
