4ISN
Crystal Structure of Matriptase in complex with its inhibitor HAI-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Kunitz-type protease inhibitor 1 | polymer | 62 | 7096.0 | 1 | UniProt (H3BR01) Pfam (PF00014) UniProt (by SIFTS) (O43278) | Homo sapiens (human) | |
| 2 | B (A) | Suppressor of tumorigenicity 14 protein | polymer | 241 | 26477.8 | 1 | UniProt (Q9Y5Y6) Pfam (PF00089) | Homo sapiens (human) | Matriptase, Membrane-type serine protease 1, MT-SP1, Prostamin, Serine protease 14, Serine protease TADG-15, Tumor-associated differentially-expressed gene 15 protein |
| 3 | C (B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 4 | D (A) | GLUTATHIONE | non-polymer | 307.3 | 1 | Chemie (GSH) | |||
| 5 | E, F (B, A) | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A: 16 - 244 (UniProt: Q9Y5Y6)
| PDB | External Database | Details |
|---|---|---|
| Gln 164 | Asn 772 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33573.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 501.5 | |
| All* | Total formula weight | 34075.3 |
