4IS8
Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nuclear receptor subfamily 5 group A member 2 | polymer | 239 | 27845.1 | 2 | UniProt (O00482) Pfam (PF00104) | Homo sapiens (human) | Alpha-1-fetoprotein transcription factor, B1-binding factor, hB1F, CYP7A promoter-binding factor, Hepatocytic transcription factor, Liver receptor homolog 1, LRH-1 |
| 2 | C, D (A, B) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B: 300 - 538 (UniProt: O00482)
| PDB | External Database | Details |
|---|---|---|
| His 419 | Gln 419 | engineered mutation |
| Thr 420 | Ala 420 | engineered mutation |
| Glu 421 | Gly 421 | engineered mutation |
| Val 422 | Ala 422 | engineered mutation |
| Ala 423 | Thr 423 | engineered mutation |
| Phe 424 | Leu 424 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 55690.3 | |
| All* | Total formula weight | 55690.3 |
