4IRV

Structure of the Helicobacter pylori CagA Oncogene Bound to the Human Tumor Suppressor Apoptosis-stimulating Protein of p53-2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Cytotoxicity-associated immunodominant antigen	polymer	221	25480.0	4	UniProt (P55980) In PDB	Helicobacter pylori	120 kDa protein, CAG pathogenicity island protein 26
2	E, F, G, H	Apoptosis-stimulating of p53 protein 2	polymer	62	6609.3	4	UniProt (Q13625) In PDB	Homo sapiens (human)	Bcl2-binding protein, Bbp, Renal carcinoma antigen NY-REN-51, Tumor suppressor p53-binding protein 2, 53BP2, p53-binding protein 2, p53BP2
3		water	water		18.0	513	Chemie (HOH)

Sequence modifications

A, B, C, D: 19 - 235 (UniProt: P55980)

PDB	External Database	Details
Gly 15	-	EXPRESSION TAG
Pro 16	-	EXPRESSION TAG
Val 17	-	EXPRESSION TAG
Asp 18	-	EXPRESSION TAG

E, F, G, H: 726 - 782 (UniProt: Q13625)

PDB	External Database	Details
Gly 721	-	EXPRESSION TAG
Pro 722	-	EXPRESSION TAG
Lys 723	-	EXPRESSION TAG
Leu 724	-	EXPRESSION TAG
Ala 725	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	128357.3
All*	Total formula weight	128357.3

*Water molecules are not included.