4IQX

Mutant P44S P169S M296I of Foot-and-mouth disease Virus RNA-dependent RNA polymerase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	3D polymerase	polymer	481	54081.3	1	UniProt (Q9QCE4) Pfam (PF00680)	Foot-and-mouth disease virus - type C
2	B (B)	RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3')	polymer	7	2236.4	1		synthetic construct
3	C (C)	RNA (5'-R(*GP*GP*CP*CP*C)-3')	polymer	5	1561.0	1		synthetic construct
4	D, E, F (A, B, C)	water	water		18.0	41	Chemie (HOH)

Sequence modifications

A: 1 - 470 (UniProt: Q9QCE4)

PDB	External Database	Details
Ser 44	Pro 1901	engineered mutation
Ser 169	Pro 2026	engineered mutation
Ile 296	Met 2153	engineered mutation
Ala 471	-	expression tag
Ala 472	-	expression tag
Leu 473	-	expression tag
Ala 474	-	expression tag
His 475	-	expression tag
His 476	-	expression tag
His 477	-	expression tag
His 478	-	expression tag
His 479	-	expression tag
His 480	-	expression tag
His 481	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	57878.7
All*	Total formula weight	57878.7

*Water molecules are not included.