4IQW
Tdt core in complex with inhibitor (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid and ssDNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | DNA nucleotidylexotransferase | polymer | 381 | 43628.7 | 1 | UniProt (P09838) Pfam (PF14716) Pfam (PF10391) Pfam (PF01909) Pfam (PF14791) In PDB | Mus musculus (mouse) | Terminal addition enzyme, Terminal deoxynucleotidyltransferase, TDT, Terminal transferase |
| 2 | C | 5'-D(*GP*CP*CP*G)-3' | polymer | 4 | 1191.8 | 1 | |||
| 3 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | A | (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid | non-polymer | 329.3 | 1 | Chemie (1FQ) | |||
| 5 | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
A: 132 - 482 (UniProt: P09838)
A: 483 - 510 (UniProt: P09838)
| PDB | External Database | Details |
|---|---|---|
| His 130 | - | expression tag |
| Met 131 | - | expression tag |
| Ala 398 | Leu 398 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44820.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 352.3 | |
| All* | Total formula weight | 45172.8 |
