4IQV

Tdt core in complex with inhibitor 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid and ssDNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	DNA nucleotidylexotransferase	polymer	400	45661.9	1	UniProt (P09838) Pfam (PF14716) Pfam (PF10391) Pfam (PF01909) Pfam (PF14791) In PDB	Mus musculus (mouse)	Terminal addition enzyme, Terminal deoxynucleotidyltransferase, TDT, Terminal transferase
2	C	5'-D(*GP*CP*CP*G)-3'	polymer	4	1191.8	1
3	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
4	A	6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid	non-polymer		329.3	1	Chemie (1FO)
5		water	water		18.0	184	Chemie (HOH)

Sequence modifications

A: 132 - 482 (UniProt: P09838)

PDB	External Database	Details
His 130	-	expression tag
Met 131	-	expression tag
Ala 398	Leu 398	engineered mutation

A: 483 - 510 (UniProt: P09838)

PDB	External Database	Details
Met 511	-	expression tag
Gly 512	-	expression tag
Ser 513	-	expression tag
Ser 514	-	expression tag
His 515	-	expression tag
His 516	-	expression tag
His 517	-	expression tag
His 518	-	expression tag
His 519	-	expression tag
His 520	-	expression tag
Ser 521	-	expression tag
Ser 522	-	expression tag
Gly 523	-	expression tag
Leu 524	-	expression tag
Val 525	-	expression tag
Pro 526	-	expression tag
Arg 527	-	expression tag
Gly 528	-	expression tag
Ser 529	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	46853.8
Non-Polymers*	Number of molecules	2
	Total formula weight	352.3
All*	Total formula weight	47206.0

*Water molecules are not included.