4IQK
Crystal structure of cpd 16 bound to Keap1 Kelch domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Kelch-like ECH-associated protein 1 | polymer | 299 | 32561.5 | 1 | UniProt (Q14145) Pfam (PF01344) | Homo sapiens (human) | Cytosolic inhibitor of Nrf2, INrf2, Kelch-like protein 19 |
| 2 | B (A) | N,N'-naphthalene-1,4-diylbis(4-methoxybenzenesulfonamide) | non-polymer | 498.6 | 1 | Chemie (IQK) | |||
| 3 | C (A) | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A: 321 - 609 (UniProt: Q14145)
| PDB | External Database | Details |
|---|---|---|
| Ser 311 | - | expression tag |
| Gly 312 | - | expression tag |
| Leu 313 | - | expression tag |
| Val 314 | - | expression tag |
| Pro 315 | - | expression tag |
| Arg 316 | - | expression tag |
| Gly 317 | - | expression tag |
| Ser 318 | - | expression tag |
| His 319 | - | expression tag |
| Met 320 | - | expression tag |
| Asn 349 | Asp 349 | conflict |
| Ala 540 | Glu 540 | engineered mutation |
| Ala 542 | Glu 542 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32561.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 498.6 | |
| All* | Total formula weight | 33060.1 |
