4IKT

Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(5-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Methionine aminopeptidase 1	polymer	329	36935.9	1	UniProt (P53582) Pfam (PF00557)	Homo sapiens (human)	MAP 1, MetAP 1, Peptidase M 1
2	B (A)	N-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-N'-[5-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine	non-polymer		408.8	1	Chemie (TFV)
3	C, D, E (A)	COBALT (II) ION	non-polymer		58.9	3	Chemie (CO)
4	F (A)	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
5	G (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	H (A)	water	water		18.0	135	Chemie (HOH)

Sequence modifications

A: 90 - 393 (UniProt: P53582)

PDB	External Database	Details
Met 65	-	expression tag
Gly 66	-	expression tag
Ser 67	-	expression tag
Ser 68	-	expression tag
His 69	-	expression tag
His 70	-	expression tag
His 71	-	expression tag
His 72	-	expression tag
His 73	-	expression tag
His 74	-	expression tag
Ser 75	-	expression tag
Ser 76	-	expression tag
Gly 77	-	expression tag
Leu 78	-	expression tag
Val 79	-	expression tag
Pro 80	-	expression tag
Arg 81	-	expression tag
Gly 82	-	expression tag
Ser 83	-	expression tag
His 84	-	expression tag
Met 85	-	expression tag
Leu 86	-	expression tag
Glu 87	-	expression tag
Asp 88	-	expression tag
Pro 89	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36935.9
Non-Polymers*	Number of molecules	6
	Total formula weight	716.8
All*	Total formula weight	37652.7

*Water molecules are not included.