4IJ8
Crystal structure of the complex of SETD8 with SAM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | N-lysine methyltransferase SETD8 | polymer | 165 | 18717.1 | 2 | UniProt (Q9NQR1) Pfam (PF00856) | Homo sapiens (human) | H4-K20-HMTase SETD8, Histone-lysine N-methyltransferase SETD8, Lysine N-methyltransferase 5A, PR/SET domain-containing protein 07, PR-Set7, PR/SET07, SET domain-containing protein 8 |
| 2 | C (I) | helical peptide | polymer | 10 | 869.1 | 1 | unidentified | ||
| 3 | D, R (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
| 4 | AA, E, F, G, H... (B, A) | UNKNOWN ATOM OR ION | non-polymer | 22 | Chemie (UNX) | ||||
| 5 | BA, CA (A, B) | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A, B: 232 - 393 (UniProt: Q9NQR1)
| PDB | External Database | Details |
|---|---|---|
| Ala 229 | - | expression tag |
| Met 230 | - | expression tag |
| Gly 231 | - | expression tag |
| Ser 343 | Cys 343 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 38303.3 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 796.9 | |
| All* | Total formula weight | 39100.2 |
