4IJ8
Crystal structure of the complex of SETD8 with SAM
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | N-lysine methyltransferase SETD8 | polymer | 165 | 18717.1 | 2 | UniProt (Q9NQR1) Pfam (PF00856) In PDB | Homo sapiens (human) | H4-K20-HMTase SETD8, Histone-lysine N-methyltransferase SETD8, Lysine N-methyltransferase 5A, PR/SET domain-containing protein 07, PR-Set7, PR/SET07, SET domain-containing protein 8 |
2 | I | helical peptide | polymer | 10 | 869.1 | 1 | unidentified | ||
3 | A, B | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
4 | B, A | UNKNOWN ATOM OR ION | non-polymer | 22 | Chemie (UNX) | ||||
5 | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A, B: 232 - 393 (UniProt: Q9NQR1)
PDB | External Database | Details |
---|---|---|
Ala 229 | - | expression tag |
Met 230 | - | expression tag |
Gly 231 | - | expression tag |
Ser 343 | Cys 343 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 38303.3 | |
Non-Polymers* | Number of molecules | 24 |
Total formula weight | 796.9 | |
All* | Total formula weight | 39100.2 |