4IGD
Crystal structure of the zymogen catalytic region of Human MASP-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mannan-binding lectin serine protease 1 | polymer | 406 | 45489.9 | 1 | UniProt (P48740) Pfam (PF00084) Pfam (PF00089) | Homo sapiens (human) | Complement factor MASP-3, Complement-activating component of Ra-reactive factor, Mannose-binding lectin-associated serine protease 1, MASP-1, Mannose-binding protein-associated serine protease, Ra-reactive factor serine protease p100, RaRF, Serine protease 5 |
| 2 | B, C (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 3 | D (A) | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
A: 298 - 699 (UniProt: P48740)
| PDB | External Database | Details |
|---|---|---|
| Ala 294 | - | expression tag |
| Ser 295 | - | expression tag |
| Met 296 | - | expression tag |
| Thr 297 | - | expression tag |
| Gln 448 | Arg 448 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45489.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 184.2 | |
| All* | Total formula weight | 45674.1 |
