4IE4
Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with 5-carboxy-8-hydroxyquinoline (IOX1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Alpha-ketoglutarate-dependent dioxygenase FTO | polymer | 495 | 56823.0 | 1 | UniProt (Q9C0B1) Pfam (PF12933) Pfam (PF12934) | Homo sapiens (human) | Fat mass and obesity-associated protein |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (A) | 8-hydroxyquinoline-5-carboxylic acid | non-polymer | 189.2 | 1 | Chemie (8XQ) | |||
| 5 | E (A) | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A: 32 - 505 (UniProt: Q9C0B1)
| PDB | External Database | Details |
|---|---|---|
| Met 11 | - | expression tag |
| Gly 12 | - | expression tag |
| Ser 13 | - | expression tag |
| Ser 14 | - | expression tag |
| His 15 | - | expression tag |
| His 16 | - | expression tag |
| His 17 | - | expression tag |
| His 18 | - | expression tag |
| His 19 | - | expression tag |
| His 20 | - | expression tag |
| Ser 21 | - | expression tag |
| Ser 22 | - | expression tag |
| Gly 23 | - | expression tag |
| Leu 24 | - | expression tag |
| Val 25 | - | expression tag |
| Pro 26 | - | expression tag |
| Arg 27 | - | expression tag |
| Gly 28 | - | expression tag |
| Ser 29 | - | expression tag |
| His 30 | - | expression tag |
| Met 31 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 56823.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 346.7 | |
| All* | Total formula weight | 57169.7 |
