4IE4

Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with 5-carboxy-8-hydroxyquinoline (IOX1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Alpha-ketoglutarate-dependent dioxygenase FTO	polymer	495	56823.0	1	UniProt (Q9C0B1) Pfam (PF12933) Pfam (PF12934) In PDB	Homo sapiens (human)	Fat mass and obesity-associated protein
2	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	A	8-hydroxyquinoline-5-carboxylic acid	non-polymer		189.2	1	Chemie (8XQ)
5		water	water		18.0	71	Chemie (HOH)

Sequence modifications

A: 32 - 505 (UniProt: Q9C0B1)

PDB	External Database	Details
Met 11	-	expression tag
Gly 12	-	expression tag
Ser 13	-	expression tag
Ser 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
Ser 21	-	expression tag
Ser 22	-	expression tag
Gly 23	-	expression tag
Leu 24	-	expression tag
Val 25	-	expression tag
Pro 26	-	expression tag
Arg 27	-	expression tag
Gly 28	-	expression tag
Ser 29	-	expression tag
His 30	-	expression tag
Met 31	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	56823.0
Non-Polymers*	Number of molecules	3
	Total formula weight	346.7
All*	Total formula weight	57169.7

*Water molecules are not included.