4IDV
Crystal Structure of NIK with compound 4-{3-[2-amino-5-(2-methoxyethoxy)pyrimidin-4-yl]-1H-indol-5-yl}-2-methylbut-3-yn-2-ol (13V)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Mitogen-activated protein kinase kinase kinase 14 | polymer | 356 | 39145.7 | 4 | UniProt (Q99558) Pfam (PF00069) In PDB | Homo sapiens (human) | NF-kappa-beta-inducing kinase, HsNIK, Serine/threonine-protein kinase NIK |
2 | A, B, C, D | 4-{3-[2-amino-5-(2-methoxyethoxy)pyrimidin-4-yl]-1H-indol-5-yl}-2-methylbut-3-yn-2-ol | non-polymer | 366.4 | 4 | Chemie (13V) | |||
3 | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 330 - 680 (UniProt: Q99558)
PDB | External Database | Details |
---|---|---|
Gly 325 | - | expression tag |
Ala 326 | - | expression tag |
Met 327 | - | expression tag |
Gly 328 | - | expression tag |
Ser 329 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 156582.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1465.7 | |
All* | Total formula weight | 158048.5 |