4IDV
Crystal Structure of NIK with compound 4-{3-[2-amino-5-(2-methoxyethoxy)pyrimidin-4-yl]-1H-indol-5-yl}-2-methylbut-3-yn-2-ol (13V)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Mitogen-activated protein kinase kinase kinase 14 | polymer | 356 | 39145.7 | 4 | UniProt (Q99558) Pfam (PF00069) | Homo sapiens (human) | NF-kappa-beta-inducing kinase, HsNIK, Serine/threonine-protein kinase NIK |
| 2 | E, F, G, H (A, B, C, D) | 4-{3-[2-amino-5-(2-methoxyethoxy)pyrimidin-4-yl]-1H-indol-5-yl}-2-methylbut-3-yn-2-ol | non-polymer | 366.4 | 4 | Chemie (13V) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 330 - 680 (UniProt: Q99558)
| PDB | External Database | Details |
|---|---|---|
| Gly 325 | - | expression tag |
| Ala 326 | - | expression tag |
| Met 327 | - | expression tag |
| Gly 328 | - | expression tag |
| Ser 329 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 156582.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1465.7 | |
| All* | Total formula weight | 158048.5 |
