4ICL

HIV-1 reverse transcriptase with bound fragment at the incoming dNTP binding site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Reverse transcriptase/ribonuclease H	polymer	557	63989.2	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus type 1 (HIV-1)	Exoribonuclease H, p66 RT
2	B	p51 RT	polymer	429	50096.5	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus type 1 (HIV-1)	Gag-Pol polyprotein
3	A	4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile	non-polymer		366.4	1	Chemie (T27)
4	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
5	A, B	DIMETHYL SULFOXIDE	non-polymer		78.1	11	Chemie (DMS)
6	A	4-(4-methylpiperazin-1-yl)benzoic acid	non-polymer		220.3	1	Chemie (14N)
7		water	water		18.0	689	Chemie (HOH)

Sequence modifications

A: 1 - 555 (UniProt: P03366)

PDB	External Database	Details
Met -1	-	expression tag
Val 0	-	expression tag
Ala 172	Lys 771	engineered mutation
Ala 173	Lys 772	engineered mutation
Ser 280	Cys 879	engineered mutation

B: 1 - 428 (UniProt: P03366)

PDB	External Database	Details
Gly 0	-	expression tag
Ser 280	Cys 879	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	114085.8
Non-Polymers*	Number of molecules	14
	Total formula weight	1470.5
All*	Total formula weight	115556.2

*Water molecules are not included.