4IBY
Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation S240R
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cellular tumor antigen p53 | polymer | 200 | 22556.7 | 2 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (human) | Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53 |
| 2 | C, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, G, H, I... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 4 | L, M (A, B) | water | water | 18.0 | 753 | Chemie (HOH) |
Sequence modifications
A, B: 94 - 293 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Arg 240 | Ser 240 | engineered mutation |
| His 273 | Arg 273 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 45113.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 565.3 | |
| All* | Total formula weight | 45678.6 |
