4IBU
Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation T284R in sequence-specific complex with DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Cellular tumor antigen p53 | polymer | 200 | 22507.6 | 4 | UniProt (P04637) Pfam (PF00870) In PDB | Homo sapiens (human) | Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53 |
| 2 | E, F, G, H | DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3') | polymer | 12 | 3664.4 | 4 | |||
| 3 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | D, A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 16 | Chemie (EDO) | |||
| 5 | H, B | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 6 | water | water | 18.0 | 959 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 94 - 293 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Cys 273 | Arg 273 | engineered mutation |
| Arg 284 | Thr 284 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 104688.0 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 1372.8 | |
| All* | Total formula weight | 106060.8 |
