4IBT
Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation T284R
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cellular tumor antigen p53 | polymer | 200 | 22542.6 | 4 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (human) | Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53 |
| 2 | E, F, G, H (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 971 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 94 - 293 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| His 273 | Arg 273 | engineered mutation |
| Arg 284 | Thr 284 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 90170.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 90432.1 |
