4IBM
Crystal structure of insulin receptor kinase domain in complex with an inhibitor Irfin-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Insulin receptor | polymer | 306 | 34809.8 | 2 | UniProt (P06213) Pfam (PF07714) | Homo sapiens (human) | IR, Insulin receptor subunit alpha, Insulin receptor subunit beta |
| 2 | C, D (A, B) | 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3H-pyrazolo[3,4-c]pyridazin-3-one | non-polymer | 326.3 | 2 | Chemie (IR1) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 554 | Chemie (HOH) |
Sequence modifications
A, B: 978 - 1283 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| Asn 1251 | Lys 1278 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69619.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 652.6 | |
| All* | Total formula weight | 70272.2 |
