4IAW
Engineered human lipocalin 2 (C26) in complex with Y-DTPA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Neutrophil gelatinase-associated lipocalin | polymer | 188 | 21573.5 | 3 | UniProt (P80188) Pfam (PF00061) | Homo sapiens (human) | NGAL, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2, p25 |
| 2 | D, F, H (A, B, C) | N-{(1S,2S)-2-[bis(carboxymethyl)amino]cyclohexyl}-N-{(2R)-2-[bis(carboxymethyl)amino]-3-[4-({[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]carbamothioyl}amino)phenyl]propyl}glycine | non-polymer | 715.8 | 3 | Chemie (LIZ) | |||
| 3 | E, G, I (A, B, C) | YTTRIUM (III) ION | non-polymer | 88.9 | 3 | Chemie (YT3) | |||
| 4 | J, K, L (A, B, C) | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 178 (UniProt: P80188)
| PDB | External Database | Details |
|---|---|---|
| His 28 | Gln 48 | engineered mutation |
| Gln 33 | Val 53 | engineered mutation |
| Arg 36 | Leu 56 | engineered mutation |
| Ala 41 | Ile 61 | engineered mutation |
| Pro 42 | Leu 62 | engineered mutation |
| Leu 48 | Pro 68 | engineered mutation |
| Leu 49 | Gln 69 | engineered mutation |
| Thr 52 | Tyr 72 | engineered mutation |
| Gln 54 | Thr 74 | engineered mutation |
| Thr 55 | Ile 75 | engineered mutation |
| Ala 68 | Ser 88 | engineered mutation |
| Arg 70 | Leu 90 | engineered mutation |
| Met 75 | Lys 95 | engineered mutation |
| Glu 77 | Asp 97 | engineered mutation |
| Leu 79 | Trp 99 | engineered mutation |
| Thr 80 | Ile 100 | engineered mutation |
| Met 81 | Arg 101 | engineered mutation |
| Ser 87 | Cys 107 | engineered mutation |
| Gln 127 | Ser 147 | engineered mutation |
| Ser 134 | Lys 154 | engineered mutation |
| Ser 136 | Thr 156 | engineered mutation |
| Leu 138 | Tyr 158 | engineered mutation |
| Ala 145 | Thr 165 | engineered mutation |
| Ser 179 | - | expression tag |
| Ala 180 | - | expression tag |
| Trp 181 | - | expression tag |
| Ser 182 | - | expression tag |
| His 183 | - | expression tag |
| Pro 184 | - | expression tag |
| Gln 185 | - | expression tag |
| Phe 186 | - | expression tag |
| Glu 187 | - | expression tag |
| Lys 188 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 64720.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2414.0 | |
| All* | Total formula weight | 67134.5 |
