4I6H
Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce alpha-Synuclein Phosphorylation in Rat Brain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase PLK2 | polymer | 308 | 35832.2 | 1 | UniProt (Q9NYY3) Pfam (PF00069) In PDB | Homo sapiens (human) | Polo-like kinase 2, PLK-2, hPlk2, Serine/threonine-protein kinase SNK, hSNK, Serum-inducible kinase |
| 2 | A | (7R)-8-cyclopentyl-7-ethyl-5-methyl-2-[2-(1,3-thiazol-4-yl)-1H-imidazol-1-yl]-7,8-dihydropteridin-6(5H)-one | non-polymer | 409.5 | 1 | Chemie (1C8) | |||
| 3 | water | water | 18.0 | 134 | Chemie (HOH) |
Sequence modifications
A: 57 - 360 (UniProt: Q9NYY3)
| PDB | External Database | Details |
|---|---|---|
| Met 53 | - | initiating methionine |
| Met 54 | - | expression tag |
| His 55 | - | expression tag |
| His 56 | - | expression tag |
| Ser 83 | Cys 83 | engineered mutation |
| Thr 87 | Val 87 | engineered mutation |
| Ser 119 | Ala 119 | engineered mutation |
| Ser 216 | Ala 216 | engineered mutation |
| Ala 259 | Cys 259 | engineered mutation |
| Ser 291 | Cys 291 | engineered mutation |
| Thr 335 | Leu 335 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35832.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 409.5 | |
| All* | Total formula weight | 36241.7 |
