4I5M
Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase PLK2 | polymer | 308 | 35832.2 | 1 | UniProt (Q9NYY3) Pfam (PF00069) | Homo sapiens (human) | Polo-like kinase 2, PLK-2, hPlk2, Serine/threonine-protein kinase SNK, hSNK, Serum-inducible kinase |
| 2 | B (A) | 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide | non-polymer | 521.7 | 1 | Chemie (R78) | |||
| 3 | C (A) | water | water | 18.0 | 268 | Chemie (HOH) |
Sequence modifications
A: 28 - 331 (UniProt: Q9NYY3)
| PDB | External Database | Details |
|---|---|---|
| Met 24 | - | expression tag |
| Met 25 | - | expression tag |
| His 26 | - | expression tag |
| His 27 | - | expression tag |
| Ser 54 | Cys 83 | engineered mutation |
| Thr 58 | Val 87 | engineered mutation |
| Ser 90 | Ala 119 | engineered mutation |
| Ser 187 | Ala 216 | engineered mutation |
| Ala 230 | Cys 259 | engineered mutation |
| Ser 262 | Cys 291 | engineered mutation |
| Thr 306 | Leu 335 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35832.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 521.7 | |
| All* | Total formula weight | 36353.8 |
