4I5C
The Jak1 kinase domain in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Tyrosine-protein kinase JAK1 | polymer | 302 | 34746.6 | 2 | UniProt (P23458) Pfam (PF07714) In PDB | Homo sapiens (human) | Janus kinase 1, JAK-1 |
| 2 | A, B | 3-oxo-3-[(3R)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6H)-yl)piperidin-1-yl]propanenitrile | non-polymer | 309.3 | 2 | Chemie (C5I) | |||
| 3 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 299 | Chemie (HOH) |
Sequence modifications
A, B: 854 - 1154 (UniProt: P23458)
| PDB | External Database | Details |
|---|---|---|
| Gly 853 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69493.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 866.9 | |
| All* | Total formula weight | 70360.1 |
