4I21
Crystal structure of L858R + T790M EGFR kinase domain in complex with MIG6 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Epidermal growth factor receptor | polymer | 329 | 37522.4 | 2 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| 2 | C, D (C, D) | ERBB receptor feedback inhibitor 1 | polymer | 62 | 6599.4 | 2 | UniProt (Q9UJM3) Pfam (PF11555) | Homo sapiens (human) | Mitogen-inducible gene 6 protein, MIG-6 |
Sequence modifications
A, B: 695 - 1022 (UniProt: P00533)
C, D: 315 - 374 (UniProt: Q9UJM3)
| PDB | External Database | Details |
|---|---|---|
| Gly 694 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Arg 858 | Leu 858 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 313 | - | expression tag |
| Ser 314 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 88243.5 | |
| All* | Total formula weight | 88243.5 |
