4I0S
Crystal structure of spleen tyrosine kinase complexed with 2-(6-Chloro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase SYK | polymer | 291 | 33884.0 | 1 | UniProt (P43405) Pfam (PF07714) | Homo sapiens (human) | Spleen tyrosine kinase, p72-Syk |
| 2 | B (A) | 2-(6-chloro-1-methyl-1H-indazol-3-yl)-N-(propan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | non-polymer | 368.8 | 1 | Chemie (1B5) | |||
| 3 | C (A) | water | water | 18.0 | 106 | Chemie (HOH) |
Sequence modifications
A: 356 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| Met 353 | - | expression tag |
| Ala 354 | - | expression tag |
| Leu 355 | - | expression tag |
| Glu 636 | - | expression tag |
| Gly 637 | - | expression tag |
| His 638 | - | expression tag |
| His 639 | - | expression tag |
| His 640 | - | expression tag |
| His 641 | - | expression tag |
| His 642 | - | expression tag |
| His 643 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33884.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 368.8 | |
| All* | Total formula weight | 34252.8 |
