4HY0
Crystal structure of XIAP BIR3 with T3256336
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | E3 ubiquitin-protein ligase XIAP | polymer | 125 | 14207.7 | 8 | UniProt (P98170) Pfam (PF00653) | Homo sapiens (human) | Baculoviral IAP repeat-containing protein 4, IAP-like protein, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP-3, hIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP |
| 2 | AA, CA, I, J, L... (G, H, A, B, C...) | ZINC ION | non-polymer | 65.4 | 14 | Chemie (ZN) | |||
| 3 | BA, DA, K, N, P... (G, H, A, B, C...) | (3S,7R,8aR)-2-{(2S)-2-(4,4-difluorocyclohexyl)-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]-7-ethoxyoctahydropyrrolo[1,2-a]pyrazine-3-carboxamide | non-polymer | 605.7 | 8 | BIRD (PRD_001138) Chemie (1AQ) | |||
| 4 | EA, FA, GA, HA, IA... (A, B, C, D, E...) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 238 - 357 (UniProt: P98170)
| PDB | External Database | Details |
|---|---|---|
| Gly 233 | - | expression tag |
| Pro 234 | - | expression tag |
| Leu 235 | - | expression tag |
| Gly 236 | - | expression tag |
| Ser 237 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 113661.7 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 5761.5 | |
| All* | Total formula weight | 119423.1 |
