4HXX
Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Methionine aminopeptidase 1 | polymer | 304 | 34178.9 | 1 | UniProt (P53582) Pfam (PF00557) | Homo sapiens (human) | MAP 1, MetAP 1, Peptidase M 1 |
| 2 | B, C, D (A) | COBALT (II) ION | non-polymer | 58.9 | 3 | Chemie (CO) | |||
| 3 | E (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 4 | F (A) | (1R)-N~2~-[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]-1-phenyl-N~1~-(4-phenylbutyl)ethane-1,2-diamine | non-polymer | 506.5 | 1 | Chemie (1AY) | |||
| 5 | G, H (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 6 | I (A) | water | water | 18.0 | 158 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34178.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 914.5 | |
| All* | Total formula weight | 35093.4 |
