4HW2
Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 153 | 17493.9 | 6 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (human) | Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT |
| 2 | G, I, M, N, O... (A, B, C, D, E...) | 6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1H-indole-2-carboxylic acid | non-polymer | 392.3 | 6 | Chemie (19H) | |||
| 3 | H, J, K (A, B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 3 | Chemie (PGE) | |||
| 4 | L (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) |
Sequence modifications
A, B, C, D, E, F: 172 - 323 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 171 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 104963.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2866.2 | |
| All* | Total formula weight | 107829.7 |
