4HVY
A thermostable variant of human NUDT18 NUDIX domain obtained by Hot Colony Filtration
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nucleoside diphosphate-linked moiety X motif 18 | polymer | 162 | 18316.0 | 1 | UniProt (Q6ZVK8) Pfam (PF00293) | Homo sapiens (human) | Nudix motif 18 |
| 2 | B, K (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 3 | C, D, G (A) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | F, H, I, J (A) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 6 | L (A) | water | water | 18.0 | 170 | Chemie (HOH) |
Sequence modifications
A: 26 - 179 (UniProt: Q6ZVK8)
| PDB | External Database | Details |
|---|---|---|
| Met 25 | - | initiating methionine |
| Met 45 | Val 45 | engineered mutation |
| Val 91 | Glu 91 | engineered mutation |
| Ala 180 | - | expression tag |
| His 181 | - | expression tag |
| His 182 | - | expression tag |
| His 183 | - | expression tag |
| His 184 | - | expression tag |
| His 185 | - | expression tag |
| His 186 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18316.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 445.1 | |
| All* | Total formula weight | 18761.2 |
