4HVV
Crystal structure of the T98E c-Src-SH3 domain mutant in complex with the high affinity peptide APP12
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Proto-oncogene tyrosine-protein kinase Src | polymer | 60 | 6847.5 | 1 | UniProt (P00523) Pfam (PF00018) In PDB | Gallus gallus (bantam chickens) | Proto-oncogene c-Src, pp60c-src, p60-Src |
2 | B | SYNTHETIC PEPTIDE Acetyl-APPLPPRNRP | polymer | 11 | 1142.4 | 1 | |||
3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
4 | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A: 85 - 140 (UniProt: P00523)
PDB | External Database | Details |
---|---|---|
Gly 81 | - | expression tag |
Ser 82 | - | expression tag |
His 83 | - | expression tag |
Met 84 | - | expression tag |
Glu 98 | Thr 98 | engineered mutation |
Arg 128 | Gln 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 7989.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 96.1 | |
All* | Total formula weight | 8085.9 |