4HVD
JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1,2,2-trimethyl-propyl)-amide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase JAK3 | polymer | 314 | 35613.6 | 1 | UniProt (P52333) Pfam (PF07714) In PDB | Homo sapiens (human) | Janus kinase 3, JAK-3, Leukocyte janus kinase, L-JAK |
| 2 | A | 1-phenylurea | non-polymer | 136.2 | 1 | Chemie (PHU) | |||
| 3 | A | 2-cyclopropyl-N-[(2S)-3,3-dimethylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | non-polymer | 286.4 | 1 | Chemie (933) | |||
| 4 | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
A: 811 - 1124 (UniProt: P52333)
| PDB | External Database | Details |
|---|---|---|
| Ser 1040 | Cys 1040 | engineered mutation |
| Ser 1048 | Cys 1048 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35613.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 422.5 | |
| All* | Total formula weight | 36036.1 |
