4HRL
Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Receptor tyrosine-protein kinase erbB-2 | polymer | 198 | 22208.3 | 1 | UniProt (P04626) Pfam (PF01030) | Homo sapiens (human) | Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2 |
| 2 | B (A) | Designed Ankyrin Repeat Protein 9_29 | polymer | 171 | 18558.7 | 1 | synthetic | ||
| 3 | C, D (C, A) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
C: 2 - 197 (UniProt: P04626)
| PDB | External Database | Details |
|---|---|---|
| His 1 | - | expression tag |
| Asp 46 | Asn 68 | engineered mutation |
| Asp 102 | Asn 124 | engineered mutation |
| Asp 165 | Asn 187 | engineered mutation |
| Ala 198 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40767.0 | |
| All* | Total formula weight | 40767.0 |
