4HOP
Crystal structure of the computationally designed NNOS-Syntrophin complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E | Alpha-1-syntrophin | polymer | 88 | 9389.8 | 3 | UniProt (Q61234) Pfam (PF00595) In PDB | Mus musculus (mouse) | 59 kDa dystrophin-associated protein A1 acidic component 1, Syntrophin-1 |
| 2 | B, D, F | Nitric oxide synthase, brain | polymer | 123 | 13289.4 | 3 | UniProt (P29476) Pfam (PF00595) In PDB | Rattus norvegicus (brown rat rat rats) | BNOS, Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS, N-NOS, nNOS, Peptidyl-cysteine S-nitrosylase NOS1 |
| 3 | water | water | 18.0 | 501 | Chemie (HOH) |
Sequence modifications
A, C, E: 77 - 162 (UniProt: Q61234)
B, D, F: 4 - 126 (UniProt: P29476)
| PDB | External Database | Details |
|---|---|---|
| Gly 75 | - | expression tag |
| Ser 76 | - | expression tag |
| Phe 142 | His 142 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 109 | Thr 109 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 68037.6 | |
| All* | Total formula weight | 68037.6 |
