4HOE
Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111E)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dihydrofolate reductase | polymer | 192 | 22194.5 | 2 | UniProt (P22906) Pfam (PF00186) | Candida albicans (yeast) | |
| 2 | C, G (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 3 | D, H (A, B) | 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | non-polymer | 388.5 | 2 | Chemie (18G) | |||
| 4 | E (A) | GLYCINE | non-polymer | 75.1 | 1 | Chemie (GLY) | |||
| 5 | F, I (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 341 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 192 (UniProt: P22906)
| PDB | External Database | Details |
|---|---|---|
| Leu 2 | Ser 2 | variant |
| Glu 84 | Lys 84 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44389.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2527.0 | |
| All* | Total formula weight | 46916.1 |
