4HMH

Crystal structure of tankyrase 2 in complex with 7,3-dihydroxyflavone

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tankyrase-2	polymer	191	21824.5	1	UniProt (Q9H2K2) Pfam (PF00644)	Homo sapiens (human)	TANK2, ADP-ribosyltransferase diphtheria toxin-like 6, ARTD6, Poly [ADP-ribose] polymerase 5B, TNKS-2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, Tankyrase II, Tankyrase-like protein, Tankyrase-related protein
2	B (C)	Tankyrase-2	polymer	49	5493.2	1	UniProt (Q9H2K2)	Homo sapiens (human)
3	C (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	D, H (A, C)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5	E (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	F (A)	7-hydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one	non-polymer		254.2	1	Chemie (F94)
7	G (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
8	I, J (A, C)	water	water		18.0	39	Chemie (HOH)

Sequence modifications

A: 946 - 1113 (UniProt: Q9H2K2)

PDB	External Database	Details
Met 923	-	expression tag
His 924	-	expression tag
His 925	-	expression tag
His 926	-	expression tag
His 927	-	expression tag
His 928	-	expression tag
His 929	-	expression tag
Ser 930	-	expression tag
Ser 931	-	expression tag
Gly 932	-	expression tag
Val 933	-	expression tag
Asp 934	-	expression tag
Leu 935	-	expression tag
Gly 936	-	expression tag
Thr 937	-	expression tag
Glu 938	-	expression tag
Asn 939	-	expression tag
Leu 940	-	expression tag
Tyr 941	-	expression tag
Phe 942	-	expression tag
Gln 943	-	expression tag
Ser 944	-	expression tag
Met 945	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	27317.8
Non-Polymers*	Number of molecules	6
	Total formula weight	710.0
All*	Total formula weight	28027.7

*Water molecules are not included.