4HJQ

SHP-1 catalytic domain WPD loop closed

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tyrosine-protein phosphatase non-receptor type 6	polymer	308	35370.8	2	UniProt (P29350) Pfam (PF00102) In PDB	Homo sapiens (human)	Hematopoietic cell protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1C, PTP-1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1
2	A, B	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
3		water	water		18.0	682	Chemie (HOH)

Sequence modifications

A, B: 243 - 528 (UniProt: P29350)

PDB	External Database	Details
Met 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag
Gly 228	-	expression tag
Ser 229	-	expression tag
Leu 230	-	expression tag
Val 231	-	expression tag
Pro 232	-	expression tag
Arg 233	-	expression tag
Ser 234	-	expression tag
Glu 235	-	expression tag
Asn 236	-	expression tag
Leu 237	-	expression tag
Tyr 238	-	expression tag
Phe 239	-	expression tag
Gln 240	-	expression tag
Gly 241	-	expression tag
Ser 242	-	expression tag
Ser 453	Cys 453	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70741.6
Non-Polymers*	Number of molecules	2
	Total formula weight	189.9
All*	Total formula weight	70931.6

*Water molecules are not included.