4HFR
Human 11beta-Hydroxysteroid Dehydrogenase Type 1 in complex with an orally bioavailable acidic inhibitor AZD4017.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Corticosteroid 11-beta-dehydrogenase isozyme 1 | polymer | 272 | 29874.6 | 2 | UniProt (P28845) Pfam (PF00106) In PDB | Homo sapiens (human) | 11-beta-hydroxysteroid dehydrogenase 1, 11-DH, 11-beta-HSD1 |
| 2 | A, B | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | A, B | {(3S)-1-[5-(cyclohexylcarbamoyl)-6-(propylsulfanyl)pyridin-2-yl]piperidin-3-yl}acetic acid | non-polymer | 419.6 | 2 | Chemie (14M) | |||
| 4 | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B: 24 - 292 (UniProt: P28845)
| PDB | External Database | Details |
|---|---|---|
| Gly 21 | - | expression tag |
| Gly 22 | - | expression tag |
| Gly 23 | - | expression tag |
| Leu 179 | Met 179 | engineered mutation |
| Arg 262 | Leu 262 | engineered mutation |
| Ser 272 | Cys 272 | engineered mutation |
| Glu 278 | Phe 278 | engineered mutation |
| Trp 286 | Met 286 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59749.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2326.0 | |
| All* | Total formula weight | 62075.1 |
