4HF4
Crystal Structure of PDE10A with a biaryl ether inhibitor (1-(1-(3-(4-(benzo[d]thiazol-2-ylamino)phenoxy)pyrazin-2-yl)piperidin-4-yl)ethanol)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 318 | 36857.4 | 2 | UniProt (Q9Y233) | Homo sapiens (human) | |
| 2 | C, D, O, P (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | E, F, G, H, I... (A, B) | SULFATE ION | non-polymer | 96.1 | 15 | Chemie (SO4) | |||
| 4 | M (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | N, X (A, B) | (1S)-1-(1-{3-[4-(1,3-benzothiazol-2-ylamino)phenoxy]pyrazin-2-yl}piperidin-4-yl)ethanol | non-polymer | 447.6 | 2 | Chemie (15H) | |||
| 6 | Y, Z (A, B) | water | water | 18.0 | 515 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73714.9 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 2689.8 | |
| All* | Total formula weight | 76404.7 |
