4HEW
Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carbonic anhydrase 2 | polymer | 260 | 29222.0 | 1 | UniProt (P00918) Pfam (PF00194) | Homo sapiens (human) | Carbonate dehydratase II, Carbonic anhydrase C, CAC, Carbonic anhydrase II, CA-II |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C, D (A) | 2-METHYLIMIDAZOLE | non-polymer | 82.1 | 2 | Chemie (2MZ) | |||
| 4 | E (A) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A: 1 - 261 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Ala 64 | His 64 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29222.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 229.6 | |
| All* | Total formula weight | 29451.6 |
