4HE2
Crystal structure of human muscle fructose-1,6-bisphosphatase Q32R mutant complex with AMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fructose-1,6-bisphosphatase isozyme 2 | polymer | 338 | 36696.0 | 1 | UniProt (O00757) Pfam (PF00316) Pfam (PF18913) | Homo sapiens (human) | FBPase 2, D-fructose-1,6-bisphosphate 1-phosphohydrolase 2 |
| 2 | B (A) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (AMP) | |||
| 3 | C (A) | PHOSPHITE ION | non-polymer | 79.0 | 1 | Chemie (PO3) | |||
| 4 | D, F, G (A) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 5 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | H (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | I (A) | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence modifications
A: 1 - 338 (UniProt: O00757)
| PDB | External Database | Details |
|---|---|---|
| Arg 32 | Gln 33 | engineered mutation |
| Leu 85 | Val 86 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36696.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 600.0 | |
| All* | Total formula weight | 37295.9 |
