4HE2
Crystal structure of human muscle fructose-1,6-bisphosphatase Q32R mutant complex with AMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fructose-1,6-bisphosphatase isozyme 2 | polymer | 338 | 36696.0 | 1 | UniProt (O00757) Pfam (PF00316) Pfam (PF18913) | Homo sapiens (human) | FBPase 2, D-fructose-1,6-bisphosphate 1-phosphohydrolase 2 |
| 2 | B (A) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (AMP) PubChem (224) PubChem (34768) PubChem (83862) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (5316444) PubChem (5742864) PubChem (12163610) PubChem (12358355) PubChem (16397049) PubChem (16760266) PubChem (40467049) PubChem (40469468) PubChem (44348067) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (46875232) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (92144436) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (12358354) PubChem (122197642) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 3 | C (A) | PHOSPHITE ION | non-polymer | 79.0 | 1 | Chemie (PO3) | |||
| 4 | D, F, G (A) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) PubChem (888) | |||
| 5 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | H (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 7 | I (A) | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence modifications
A: 1 - 338 (UniProt: O00757)
| PDB | External Database | Details |
|---|---|---|
| Arg 32 | Gln 33 | engineered mutation |
| Leu 85 | Val 86 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36696.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 600.0 | |
| All* | Total formula weight | 37295.9 |
