4HDQ
Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and the Heart of Glass (HEG1) cytoplasmic tail
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Krev interaction trapped protein 1 | polymer | 322 | 37372.3 | 1 | UniProt (O00522) Pfam (PF00373) In PDB | Homo sapiens (human) | KRIT1, Krev interaction trapped 1, Cerebral cavernous malformations 1 protein |
| 2 | B | Ras-related protein Rap-1b | polymer | 167 | 19020.5 | 1 | UniProt (P61224) Pfam (PF00071) In PDB | Homo sapiens (human) | Rap1B, GTP-binding protein smg p21B |
| 3 | C | Protein HEG homolog 1 | polymer | 26 | 3170.5 | 1 | UniProt (Q9ULI3) In PDB | Homo sapiens | HEG1 |
| 4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | B | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | B | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 7 | water | water | 18.0 | 93 | Chemie (HOH) |
Sequence modifications
A: 417 - 736 (UniProt: O00522)
| PDB | External Database | Details |
|---|---|---|
| Gly 415 | - | expression tag |
| Ala 416 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 59563.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 638.6 | |
| All* | Total formula weight | 60201.9 |
