4HDF
Crystal Structure of HIV-1 protease mutants V82A complexed with inhibitor GRL-0519
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | HIV-1 Protease | polymer | 99 | 10712.6 | 2 | UniProt (P03367) Pfam (PF00077) In PDB | Human immunodeficiency virus type 1 (HIV-1) | PR, Retropepsin |
2 | B | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
3 | A | (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate | non-polymer | 604.7 | 1 | Chemie (G52) | |||
4 | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
B, A: 1 - 99 (UniProt: P03367)
PDB | External Database | Details |
---|---|---|
Lys 7 | Gln 507 | engineered mutation |
Ile 33 | Leu 533 | engineered mutation |
Ile 63 | Leu 563 | engineered mutation |
Ala 67 | Cys 567 | engineered mutation |
Ala 82 | Val 582 | engineered mutation |
Ala 95 | Cys 595 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 21425.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 640.2 | |
All* | Total formula weight | 22065.4 |