4HCR
Crystal structure of human MAdCAM-1 D1D2 complexed with Fab PF-547659
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (H, M) | PF-547659 heavy chain | polymer | 229 | 24484.2 | 2 | Homo sapiens (human) | ||
| 2 | B, E (L, N) | PF-547659 light chain | polymer | 219 | 24166.0 | 2 | Homo sapiens (human) | ||
| 3 | C, F (A, B) | Mucosal addressin cell adhesion molecule 1 | polymer | 209 | 22348.3 | 2 | UniProt (Q13477) Pfam (PF09085) | Homo sapiens (human) | MAdCAM-1, hMAdCAM-1 |
| 4 | G, H, I, J, K... (H, L, A, M, N...) | water | water | 18.0 | 1016 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 203 (UniProt: Q13477)
| PDB | External Database | Details |
|---|---|---|
| Asn 94 | Asp 116 | engineered mutation |
| His 204 | - | expression tag |
| His 205 | - | expression tag |
| His 206 | - | expression tag |
| His 207 | - | expression tag |
| His 208 | - | expression tag |
| His 209 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 141997.0 | |
| All* | Total formula weight | 141997.0 |
