4HC1
Crystal structure of a loop deleted mutant of human MAdCAM-1 D1D2 complexed with Fab 10G3
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Mucosal addressin cell adhesion molecule 1 | polymer | 206 | 21699.8 | 2 | UniProt (Q13477) Pfam (PF09085) In PDB | Homo sapiens (human) | MAdCAM-1, hMAdCAM-1 |
2 | H, M | 10G3 heavy chain | polymer | 220 | 23688.4 | 2 | Mus musculus (mouse) | ||
3 | L, N | 10G3 light chain | polymer | 214 | 23570.0 | 2 | Mus musculus (mouse) | ||
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
5 | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 202 (UniProt: Q13477)
PDB | External Database | Details |
---|---|---|
Asn 94 | Asp 116 | engineered mutation |
Gln 148 | Glu 170 | engineered mutation |
- | Glu 172 | deletion |
- | Glu 173 | deletion |
- | Glu 174 | deletion |
- | Pro 175 | deletion |
- | Gln 176 | deletion |
- | Gly 177 | deletion |
- | Gln 178 | deletion |
- | Gly 179 | deletion |
Pro 150 | - | insertion |
Ile 151 | - | insertion |
Gly 152 | - | insertion |
Gly 153 | - | insertion |
Gly 203 | - | expression tag |
Gly 204 | - | expression tag |
Glu 205 | - | expression tag |
Asn 206 | - | expression tag |
Leu 207 | - | expression tag |
Tyr 208 | - | expression tag |
Phe 209 | - | expression tag |
Gln 210 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 137916.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 442.4 | |
All* | Total formula weight | 138358.9 |