4HBQ
Crystal structure of a loop deleted mutant of Human MAdCAM-1 D1D2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mucosal addressin cell adhesion molecule 1 | polymer | 206 | 21699.8 | 2 | UniProt (Q13477) Pfam (PF09085) | Homo sapiens (human) | MAdCAM-1, hMAdCAM-1 |
| 2 | C, E (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 508 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 202 (UniProt: Q13477)
| PDB | External Database | Details |
|---|---|---|
| Asn 94 | Asp 116 | engineered mutation |
| Gln 148 | Glu 170 | engineered mutation |
| - | Glu 172 | deletion |
| - | Glu 173 | deletion |
| - | Glu 174 | deletion |
| - | Pro 175 | deletion |
| - | Gln 176 | deletion |
| - | Gly 177 | deletion |
| - | Gln 178 | deletion |
| - | Gly 179 | deletion |
| Pro 150 | - | insertion |
| Ile 151 | - | insertion |
| Gly 152 | - | insertion |
| Gly 153 | - | insertion |
| Gly 203 | - | expression tag |
| Gly 204 | - | expression tag |
| Glu 205 | - | expression tag |
| Asn 206 | - | expression tag |
| Leu 207 | - | expression tag |
| Tyr 208 | - | expression tag |
| Phe 209 | - | expression tag |
| Gln 210 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43399.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 505.4 | |
| All* | Total formula weight | 43905.0 |
