4H6J
Identification of Cys 255 in HIF-1 as a novel site for development of covalent inhibitors of HIF-1 /ARNT PasB domain protein-protein interaction.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HYPOXIA INDUCIBLE FACTOR 1-ALPHA | polymer | 113 | 13051.6 | 1 | UniProt (Q16665) Pfam (PF08447) | Homo sapiens | |
| 2 | B (B) | ARYL HYDROCARBON NUCLEAR TRANSLOCATOR | polymer | 116 | 13640.4 | 1 | UniProt (P27540) Pfam (PF14598) | Homo sapiens | |
| 3 | C, D (A, B) | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence modifications
A: 238 - 348 (UniProt: Q16665)
B: 357 - 470 (UniProt: P27540)
| PDB | External Database | Details |
|---|---|---|
| Gly 236 | - | expression tag |
| Ser 237 | - | expression tag |
| Glu 245 | Arg 245 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 355 | - | expression tag |
| Ser 356 | - | expression tag |
| Arg 362 | Glu 362 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26692.0 | |
| All* | Total formula weight | 26692.0 |
