4H6J

Identification of Cys 255 in HIF-1 as a novel site for development of covalent inhibitors of HIF-1 /ARNT PasB domain protein-protein interaction.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	HYPOXIA INDUCIBLE FACTOR 1-ALPHA	polymer	113	13051.6	1	UniProt (Q16665) Pfam (PF08447) In PDB	Homo sapiens
2	B	ARYL HYDROCARBON NUCLEAR TRANSLOCATOR	polymer	116	13640.4	1	UniProt (P27540) Pfam (PF14598) In PDB	Homo sapiens
3		water	water		18.0	154	Chemie (HOH)

Sequence modifications

A: 238 - 348 (UniProt: Q16665)

PDB	External Database	Details
Gly 236	-	expression tag
Ser 237	-	expression tag
Glu 245	Arg 245	engineered mutation

B: 357 - 470 (UniProt: P27540)

PDB	External Database	Details
Gly 355	-	expression tag
Ser 356	-	expression tag
Arg 362	Glu 362	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	26692.0
All*	Total formula weight	26692.0

*Water molecules are not included.