4H65

Crystal structure of SeMet derivative of HMP synthase Thi5 from S. cerevisiae

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Pyrimidine precursor biosynthesis enzyme THI5	polymer	346	39751.4	2	UniProt (P43534) Pfam (PF09084) In PDB	Saccharomyces cerevisiae (yeast)	HMP synthase Thi5
2		water	water		18.0	109	Chemie (HOH)

Sequence modifications

A, B: 1 - 340 (UniProt: P43534)

PDB	External Database	Details
Ser 240	Lys 240	ENGINEERED MUTATION
Gly 241	Glu 241	ENGINEERED MUTATION
Thr 317	Gln 317	ENGINEERED MUTATION
His 341	-	EXPRESSION TAG
His 342	-	EXPRESSION TAG
His 343	-	EXPRESSION TAG
His 344	-	EXPRESSION TAG
His 345	-	EXPRESSION TAG
His 346	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	79502.8
All*	Total formula weight	79502.8

*Water molecules are not included.