4H53
Influenza N2-Tyr406Asp neuraminidase in complex with beta-Neu5Ac
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Neuraminidase | polymer | 388 | 43006.7 | 4 | UniProt (Q194T1) Pfam (PF00064) | Influenza A virus | |
| 2 | E (E) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G55220VL) | |||
| 3 | F, I, L (F, I, L) | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose | branched | 471.4 | 3 | In PDB GlyTouCan (G30207PZ) | |||
| 4 | G, H, J, K (G, H, J, K) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 4 | In PDB GlyTouCan (G81315DD) | |||
| 5 | M (M) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | N (N) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
| 7 | O, R, T (A, B, C) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 8 | P (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 9 | Q, S, U (A, B, C) | N-acetyl-beta-neuraminic acid | non-polymer | 309.3 | 3 | Chemie (SLB) | |||
| 10 | V (D) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 11 | W, X, Y, Z (A, B, C, D) | water | water | 18.0 | 2186 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 82 - 469 (UniProt: Q194T1)
| PDB | External Database | Details |
|---|---|---|
| Asp 406 | Tyr 406 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 172026.8 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 7141.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1361.3 | |
| All* | Total formula weight | 180529.5 |
