4H4F

Crystal structure of human chymotrypsin C (CTRC) bound to inhibitor eglin c from Hirudo medicinalis

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Chymotrypsin-C	polymer	249	28054.8	1	UniProt (Q99895) Pfam (PF00089) In PDB	Homo sapiens (human)	Caldecrin
2	B	Eglin C	polymer	70	8072.1	1	UniProt (P01051) Pfam (PF00280) In PDB	Hirudo medicinalis (Medicinal leech)
3	Q	Chymotrypsin-C	polymer	10	1030.2	1	UniProt (Q99895) In PDB	Homo sapiens (human)	Caldecrin
4	A, B	PHOSPHATE ION	non-polymer		95.0	3	Chemie (PO4)
5		water	water		18.0	320	Chemie (HOH)

Sequence modifications

A: 16 - 244 (UniProt: Q99895)

PDB	External Database	Details
His 245	-	EXPRESSION TAG
His 246	-	EXPRESSION TAG
His 247	-	EXPRESSION TAG
His 248	-	EXPRESSION TAG
His 249	-	EXPRESSION TAG
His 250	-	EXPRESSION TAG
His 251	-	EXPRESSION TAG
His 252	-	EXPRESSION TAG
His 253	-	EXPRESSION TAG
His 254	-	EXPRESSION TAG

B: 8 - 70 (UniProt: P01051)

PDB	External Database	Details
Met 1	-	EXPRESSION TAG
Ser 2	-	EXPRESSION TAG
Met 3	-	EXPRESSION TAG
Gly 4	-	EXPRESSION TAG
Ser 5	-	EXPRESSION TAG
Glu 6	-	EXPRESSION TAG
Leu 7	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	37157.1
Non-Polymers*	Number of molecules	3
	Total formula weight	284.9
All*	Total formula weight	37442.0

*Water molecules are not included.