4H3P

Crystal structure of human ERK2 complexed with a MAPK docking peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, D)	Mitogen-activated protein kinase 1	polymer	362	41444.6	2	UniProt (P28482) Pfam (PF00069)	Homo sapiens (human)	MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2
2	C, D (B, E)	Ribosomal protein S6 kinase alpha-1	polymer	24	2664.2	2	UniProt (Q15418)	Homo sapiens	S6K-alpha-1, 90 kDa ribosomal protein S6 kinase 1, p90-RSK 1, p90RSK1, p90S6K, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, Ribosomal S6 kinase 1, RSK-1
3	E, F (A, D)	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)
4	G, H (A, D)	water	water		18.0	177	Chemie (HOH)

Sequence modifications

A, D: 1 - 360 (UniProt: P28482)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag
Ala 77	Arg 77	engineered mutation
Ala 314	Glu 314	engineered mutation

B, E: 712 - 735 (UniProt: Q15418)

PDB	External Database	Details
Ala 719	Ser 719	engineered mutation
Ala 724	Gln 724	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	88217.7
Non-Polymers*	Number of molecules	2
	Total formula weight	1012.4
All*	Total formula weight	89230.1

*Water molecules are not included.