4H0V
Crystal structure of NAD+-Ia(E378S)-actin complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Iota toxin component Ia | polymer | 418 | 48177.1 | 1 | UniProt (Q46220) | Clostridium perfringens | |
| 2 | B (B) | Actin, alpha skeletal muscle | polymer | 375 | 41862.6 | 1 | UniProt (P68135) Pfam (PF00022) | Oryctolagus cuniculus (rabbit) | Alpha-actin-1 |
| 3 | C (A) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 1 | Chemie (NAD) | |||
| 4 | D (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) PubChem (1061) | |||
| 5 | AA, BA, CA, DA, E... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 39 | Chemie (EDO) | |||
| 6 | X (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) PubChem (271) | |||
| 7 | Y (B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 8 | Z (B) | LATRUNCULIN A | non-polymer | 421.6 | 1 | Chemie (LAR) PubChem (20054953) PubChem (3891) PubChem (22832181) PubChem (22832298) PubChem (24816451) PubChem (24832051) PubChem (16760535) PubChem (107993) PubChem (53237841) PubChem (46936439) PubChem (445420) PubChem (57484570) PubChem (76327939) PubChem (89005581) PubChem (14133242) PubChem (70701335) PubChem (70820543) PubChem (91886139) PubChem (5353711) PubChem (5459089) PubChem (5943927) PubChem (9931975) PubChem (6437378) PubChem (10387471) PubChem (124526973) PubChem (124674678) PubChem (14133244) PubChem (162879224) PubChem (162879223) PubChem (134688496) PubChem (146159700) PubChem (162879221) PubChem (162879222) PubChem (162879225) PubChem (166640061) PubChem (168314144) | |||
| 9 | UA, VA (A, B) | water | water | 18.0 | 218 | Chemie (HOH) |
Sequence modifications
A: 1 - 413 (UniProt: Q46220)
| PDB | External Database | Details |
|---|---|---|
| Arg -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ser 378 | Glu 419 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 90039.8 | |
| Non-Polymers* | Number of molecules | 44 |
| Total formula weight | 4147.9 | |
| All* | Total formula weight | 94187.6 |
