4H0V
Crystal structure of NAD+-Ia(E378S)-actin complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Iota toxin component Ia | polymer | 418 | 48177.1 | 1 | UniProt (Q46220) Pfam (PF03496) | Clostridium perfringens | |
| 2 | B (B) | Actin, alpha skeletal muscle | polymer | 375 | 41862.6 | 1 | UniProt (P68135) Pfam (PF00022) | Oryctolagus cuniculus (rabbit) | Alpha-actin-1 |
| 3 | C (A) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 1 | Chemie (NAD) | |||
| 4 | D (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | AA, BA, CA, DA, E... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 39 | Chemie (EDO) | |||
| 6 | X (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | Y (B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 8 | Z (B) | LATRUNCULIN A | non-polymer | 421.6 | 1 | Chemie (LAR) | |||
| 9 | UA, VA (A, B) | water | water | 18.0 | 218 | Chemie (HOH) |
Sequence modifications
A: 1 - 413 (UniProt: Q46220)
| PDB | External Database | Details |
|---|---|---|
| Arg -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ser 378 | Glu 419 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 90039.8 | |
| Non-Polymers* | Number of molecules | 44 |
| Total formula weight | 4147.9 | |
| All* | Total formula weight | 94187.6 |
